Preventing Polio Post-Eradication: Elucidating Polio Virus Shedding and Transmission Patterns in the Presence of Inactivated Polio Vaccine and Oral Polio Vaccine

Next Generation Inactivated Polio Vaccine Manufacturing to Support Post Polio-Eradication Biosafety Goals

Worldwide efforts to eradicate polio caused a tipping point in polio vaccination strategies. A switch from the oral polio vaccine, which can cause circulating and virulent vaccine derived polioviruses, to inactivated polio vaccines (IPV) is scheduled. Moreover, a manufacturing process, using attenuated virus strains instead of wild-type polioviruses, is demanded to enhance worldwide production ...

Polio vaccine development in Canada: contributions to global polio eradication.

The paper briefly describes Canada's distinctive experience in the control of polio and offers some lessons for governments and health policy leaders in other jurisdictions, particularly as they consider immunization policies for the post-polio-eradication era.

Inactivated Polio Vaccine: Its proposed role in the final stages of polio eradication

In 2000, the island of Hispaniola, home to Haiti and the Dominican Republic, was the first place where the existence of circulating vaccine derived poliovirus (cVDPV) was demonstrated [1]. As a live product, oral polio vaccine (OPV), once excreted, could enter the environment, reassort with other enteroviruses, and produce cVDPV [2]. After the investigation of that outbreak, the first of a doze...

Monovalent oral polio vaccine: Gates Foundation funds new polio vaccine to accelerate eradication efforts.

Polio eradication. Efficacy of inactivated poliovirus vaccine in India.

Inactivated poliovirus vaccine (IPV) is efficacious against paralytic disease, but its effect on mucosal immunity is debated. We assessed the efficacy of IPV in boosting mucosal immunity. Participants received IPV, bivalent 1 and 3 oral poliovirus vaccine (bOPV), or no vaccine. A bOPV challenge was administered 4 weeks later, and excretion was assessed 3, 7, and 14 days later. Nine hundred and ...